Liverpool head coach Jurgen Klopp said on Sunday that says centre-backs Virgil van Dijk and Joe Gomez could miss this summer's European Championship.
Netherlands international Van Dijk has been ruled out of the squad since the beginning of the season as he had surgery after suffering knee ligament damage in October.
Gomez was injured on England duty in November and had an operation to repair a tendon in his left knee.
"Joe is not running, Virgil is already running but this is a real tough one," said Klopp, according to BBC.
The Euros are set to take place between 11 June and 11 July, having been delayed by a year because of the coronavirus pandemic.
"It's not that I don't let them go, it is because of the extent of the injuries.
"We all hope they will be ready to start pre-season with us, that's what we all hope. With Joel [Matip] it is pretty much the same.
"These are really serious injuries and it is now not about talking about which competition they play.
"I am always open for positive surprises and they all of a sudden turn up in team training - but no-one told me that."
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