Several hundred protesters turned out in Berlin, the capital city of Germany, for the second day in a row, staging a rally outside the US Embassy.
Demonstrators held up signs reading: "Stop killing us" and "Justice for George Floyd."
Hamburg police have dispersed Black Lives Matter, a pro-African-Americans movement, protesters.
Police in the northern German city of Hamburg intervened in an anti-racism protest, declaring the rally over after just 30 minutes.
Security forces claimed that gatherings across the country are a violation of Coronavirus restrictions.
Germany held the largest demonstrations over the death of George Floyd outside the US on Friday.
Authorities pretended that the attendees had violated police instructions to adhere to Coronavirus rules such as wearing face masks and maintaining physical distancing.
Around 4,500 people attended the protest outside the city's US consulate along the banks of the Alster river.
The event had originally been registered for only 250 participants. The rally was registered under the slogan: "Justice for Floyd - stop killing blacks - stop the racial terrorism in the USA.
Crowds did not immediately disperse following police instructions with photos posted on social media showing people sitting instead on the ground.
Protest organizers appealed to demonstrators to go home peacefully. The rally eventually started to break up in the late afternoon on Friday.
The largest anti-racism demonstrations outside of the US on Friday appeared to be in Germany. In addition to the Hamburg protest, thousands of people rallied in Germany's financial hub, Frankfurt.
Protesters were seen with raised hands in the air, holding banners with slogans such as: "Your Pain Is My Pain, Your Fight Is My Fight."
In reference to the George Floyd killing caught on camera by bystanders in Minneapolis, one poster at a Frankfurt demonstration read: "How Many Weren't Filmed?"
Police described the Frankfurt demonstration as peaceful and said that those attending had followed the rules introduced to curb the spread of the Coronavirus, including wearing face masks.