Meteorological experts believe that severe weather conditions can impact millions of travelers.
Flight or trip delays could ruin the schedules of millions of travelers across the US ahead of Thanksgiving.
Nearly 80 million people are expected to travel in various ways, including road trips, and cruises, during Thanksgiving, according to AAA.
The organization said that nearly 72 million people will travel by car over the holiday period and about 6 million will travel by plane across the US.
More than 50,000 flights took off Tuesday and around 50,000 are expected to fly on Wednesday, according to the Federal Aviation Administration.
Until now, more than 1,000 flights in, out, and within the US were delayed on Tuesday, according to FlightAware.
The majority of delays were at airports are not because of air traffic controller staffing, but "weather and volume," which drive nearly all delays, according to the FAA.
The FAA added: "For the Thanksgiving holiday travel period, the FAA will implement traffic flow management initiatives to address any staffing shortages as needed."
Transportation Security Administration chief David Pekoske said on Tuesday that fliers to "pack a little patience" and understanding as they make their travel plans.
"Travelers: Airports will be busy today and tomorrow. Please be sure to arrive at least 2 hours early for domestic and 3 hours for international flights," Pekoske added.