Italy's former Minister of Foreign Affairs Franco Frattini died on Saturday at the age of 65, Italian media reported.
Frattini died with cancer in a hospital in Rome.
He was Minister of Foreign Affairs in the governments of Prime Minister Silvio Berlusconi 2002-2004 and 2008-2011.
He also held two other ministerial posts in the governments of Berlusconi and Lamberto Dini in the 1990s.
From 2004 to 2008 he was European Commissioner for Justice, and at the time of his death he was President of the Italian Council of State, an advisory body that oversees public administration.
He started his political activity as a member of the Socialist Party and later joined Berlusconi's centre-right parties.