Liverpool captain Jordan Henderson will be out of the Reds' squad for up to 10 weeks after suffering from groin injury, which he sustained during Everton's clash.
The England midfielder, 30, was forced off in the first half in Saturday's 2-0 Merseyside derby defeat to add to the club's defensive problems.
He joined Virgil van Dijk, Joel Matip, Joe Gomez and Fabinho on the sidelines.
Henderson has had surgery and will miss three England World Cup qualifiers but is expected to return this season.
The midfielder has been used in defence in recent weeks with Jurgen Klopp without his three main centre-backs.