Ramos, Thiago, and De Gea will miss Spain's squad for 2022 World Cup set to take place on November 18th.
The tournament will take place in Qatar.
Luis Enrique decided to exclude the trio from the 26-man squad for the World Cup.
The Full Squad:
Goalkeepers: Unai Simon, David Raya, Robert Sanchez
Defenders: Pau Torres, Jordi Alba, Jose Gaya, Hugo Guillamon, Eric Garcia, Cesar Azpilicueta, Dani Carvajal, Aymeric Laporte
Midfielders: Sergio Busquets, Rodri, Pedri, Koke, Gavi, Carlos Soler, Marcos Llorente
Forwards: Pablo Sarabia, Nico Williams, Marco Asensio, Alvaro Morata, Ansu Fati, Yeremy Pino, Ferran Torres, Dani Olmo