Manchester City's manager Pep Guardiola said on Saturday that midfielder Kevin de Bruyne will be ruled out for four to six weeks with a hamstring injury.
The Belgium playmaker, 29, suffered the injury during Wednesday's 2-0 Premier League win against Aston Villa.
His absence will start with Saturday's FA Cup fourth-round tie at Cheltenham.
De Bruyne could miss up to 10 matches, including the Champions League last-16 first-leg tie with Borussia Monchengladbach on 24 February.
"The doctor said after reviewing the scan Kevin will be out for four to six weeks. It's a big blow, but we have to move forward," said Guardiola.
"I'm not saying anything that anyone doesn't know - it is unfortunate for him and for us and we have to find a solution because everyone in their own life is struggling in the situation we are living in and we have to adapt."
City are unbeaten in 16 games in all competitions, including wins in all their past nine matches, and are second in the Premier League, two points behind Manchester United, but with a game in hand.
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